Abstract:To understand the epidemic of measles in China in the past 20 years, such that to provide important information for dynamical models and to provide theoretical basis and suggestions for control measures to eliminate measles. Reviewed related literature in the past two decades on studies of measles in China, including the epidemiology characteristics of measles, vaccination coverage, supplemental immunization activities (SIA) and their effects, serological investigation in population and the possible driving factors for cases annual seasonality. Reported cases in the post-vaccination era still had annual seasonality, however seasonal peak shifted to late Spring; case percentage in age groups shifted and the percentage in elder population increased; the overall immunization rate of measles in China has reached a high level, but the vaccination coverage in urban and rural areas are uneven; SIA had significant effect on the reduction of measles cases there is a significant correlation between the number of cases of measles and the environmental factors. A nationwide comparative analysis in the epidemiology of measles is lack; it is necessary to study the vaccination coverage difference between rural and urban areas; it is worth to apply dynamical transmission models to analyze the persistent prevalence of measles in China even though there has been a high level vaccination implemented.
方海旭, 赵继军. 近20年中国麻疹的流行与防控[J]. 复杂系统与复杂性科学, 2018, 15(1): 86-93.
FANG Haixu, ZHAO Jijun. Measles and Its Control in China in the Past Two Decades. Complex Systems and Complexity Science, 2018, 15(1): 86-93.
[1]World Health Organization. Measles fact sheet N 286. 2012[DB/OL]. [20180115]. http://www.who.int/mediacentre/factsheets/fs286/en/. [2]Tu B, Zhao J J, Hu Y, et al. Clinical and immunological analysis of measles patients admitted to a Beijing hospital in 2014 during an outbreak in China [J]. Epidemiology & Infection, 2016, 144(12): 26132620. [3]World Health Organization. Global measles and rubella strategic plan: 2012 [DB/OL]. [20180115]. http://apps.who.int/iris/handle/10665/44855. [4]张括生, 尚莉丽. 建国60年来麻疹流行病学特点及其防治措施[J]. 中医药临床杂志, 2011, 23(9): 759762. Zhang Kuosheng, Shang Lili. Epidemiological characteristics and preventive measures of measles in the past 60 years since the founding of the people's Republic of China[J]. Clinical Journal of Traditional Chinese Medicine, 2011, 23(9): 759762. [5]郁新. 海门市1956—2001年麻疹发病趋势分析[J]. 职业与健康, 2003. 19(1): 63. Yu Xin. The epidemic trend of measles in Haimen city[J]. Occupation and Health, 2003. 19(1): 63. [6]张荣珍, 张东. 我国建国以来麻疹疫情动态与流行特征分析[J]. 中华流行病学杂志, 1980. 10(1): 1. Zhang Rongzhen, Zhang Dong. Epidemiological characteristics and epidemiological characteristics of measles since the founding of new China[J]. Chinese Journal of Epidemiology, 1980. 10(1): 1. [7]聪敏, 李林泽. 保定地区2007年麻疹流行病学调查[J]. 职业与健康. 2008, 24(17): 17. Cong Min, Li Linze. Epidemiological investigation of measles in Baoding area in 2007[J]. Occupation and Health, 2008, 24(17): 17. [8]罗小铭, 张晋昕. 全球麻疹消除的意义与发展现状[J]. 医学综述, 2008, 14(1): 119121. Luo Xiaoming, Zhang Jinxin. Significance and development status of measles elimination in global[J]. Medical Recapitulate, 2008, 14(1): 119121. [9]王德明, 徐相凯. 麻疹疫苗及其应用[J]. 中国病原生物学杂志, 2008, 3(9): 708710. Wang Deming, Xu Xiangkai. Measles vaccine and its application[J]. Journal of Pathogen Biology, 2008, 3(9): 708710. [10] 英忠. 瑞金市1950—2001年麻疹流行特征分析[J]. 中国预防医学杂志, 2008, 4(3): 176. Ying Zhong. Analysis of the epidemic characteristics of measles in Ruijin in 19502001[J]. Chinese Journal of Preventive Medicine, 2008, 4(3): 176. [11] 马超, 郝利新, 苏琪茹, 等. 中国2014年麻疹流行病学特征分析[J]. 疾病监测, 2015, 30(10): 818823. Ma Chao, Hao Lixin, Su Qiru, et al. Measles epidemiology in China, 2014[J]. Disease Surveillance, 2015, 30(10): 818823. [12] 闫绍宏, 李彬, 冯中强, 等. 内蒙古自治区2013年麻疹流行病学特征分析及麻疹疫苗的接种情况[J]. 中国生物制品学杂志, 2017 (1): 5962. Yan Shaohong, Li Bin, Feng Zhongqiang, et al. Epidemiological characteristics of measles and inoculation of measles vaccine in inner Mongolia autonomous region in 2013[J]. Chinese Journal of Biologicals, 2017(1): 5962. [13] 刘国栋, 蔡庭玉, 汤腾龙, 等. 深圳某区2009—2014年418例成人麻疹病例流行病学分析[J]. 热带医学杂志, 2015, 15(6): 836838. Liu Guodong, Cai Tingyu, Tang Tenglong, et al. Epidemiological analysis of 418 adult measles in a district of Shenzhen during 20092014[J]. Journal of Tropical Medicine, 2015, 15(6): 836838. [14] 谢元忠, 张先慧, 郝静, 等. 2009—2012年济南市麻疹流行病学特征及消除麻疹策略探讨[J]. 现代预防医学, 2015, 42(20): 36613663, 3667. Xie Yuanzhong, Zhang Xianhui, Hao Jing, et al. Measles epidemiology and elimination strategies in Jinan between 2009 and 2012[J]. Modern Preventive Medicine, 2015, 42(20): 36613663, 3667. [15] 韩书珍, 叶颖子, 曹凌峰, 等. 2012年上海地区麻疹住院儿童临床及流行病学特征分析[J]. 中华儿科杂志, 2015, 53(8): 605609. Han Shuzhen, Ye Yingzi, Cao Lingfeng, et al. Analysis on clinical and epidemiological characteristics of measles in hospitalized children in Shanghai in 2012[J]. Chinese Journal of Pediatrics, 2015, 53(8): 605609. [16] Li S, Ma C, Hao L, et al. Demographic transition and the dynamics of measles in six provinces in China: a modeling study [J]. PLoS Medicine, 2017, 14(4): e1002255. [17] 姚宁, 刘洋, 王青, 等. 2009—2012年重庆市麻疹流行特征分析[J]. 热带医学杂志, 2015, 15(9): 12661268. Yao Ning, Liu Yang, Wang Qing, et al. Measles epidemiological characteristics of Chongqing, 20092012[J]. Journal of Tropical Medicine, 2015, 15(9): 12661268. [18] 蔡军, 郑珂, 王艳梅, 等. 2009—2014年成都市本市及流动人口麻疹流行病学特征分析[J].预防医学情报杂志, 2016, 32(4): 372375. Cai Jun, Zheng Ke, Wang Yanmei, et al. Epidemic characteristics of measles in Chengdu local population and floating population[J]. Journal of Preventive Medicine Information, 2016, 32(4): 372375. [19] 李雯雯, 李亚斐. 2007—2014年重庆市合川区麻疹流行病学特征分析[J]. 预防医学情报杂志, 2016, 32(11): 12011205. Li Wenwen, Li Yafei. Analyze the epidemic characteristic measles in Hechuan district Chongqing city from 2007 to 2014[J]. Journal of Preventive Medicine Information, 2016, 32(11): 12011205. [20] 邓舒, 王建军, 刘永孝, 等. 2014年安徽省麻疹病例发病年龄分析及原因探讨[J]. 疾病监测, 2016, 31(4): 303307. Deng Shu, Wang Jianjun, Liu Yongquan, et al. Age distribution of measles cases and related factors in Anhui, 2014[J], Disease Surveillance, 2016, 31(4): 303307. [21] 宋素芳, 梁智辉, 骆金俊, 等. 2009—2014年湖北黄冈市麻疹流行病学特征分析[J]. 公共卫生与预防医学, 2016, 27(2): 105107. Song Sufang, Liang Zhihui, Luo Jinjun, et al. Analysis on epidemiological characteristics of measles in Huanggang city, Hubei province from 2009 to 2014[J]. Journal of Public Health and Preventive Medicine, 2016, 27(2): 105107. [22] 张嘉陵, 许雷, 谷利妞, 等. 2005—2013年连云港市麻疹流行病学特征[J]. 职业与健康, 2015, 31(9): 23. Zhang Jialing, Xu Lei, Gu Liniu, et al. Analysis on epidemiological characteristics of measles in Lianyungang city from 20052013[J]. Occupation and Health, 2015, 31(9): 23. [23] 宋全伟, 苏琪茹, 马超, 等. 2005—2014年中国麻疹空间自相关分析[J]. 中华预防医学杂志, 2016, 50(7): 615619. Song Quanwei, Su Qiru, Ma Chao, et al. Spatial autocorrelation analysis of measles in China, 20052014[J], Chinese Journal of Preventive Medicine, 2016, 50(7): 615619. [24] Yang W, Wen L, Li S L, et al. Geospatial characteristics of measles transmission in China during 20052014 [J]. PLoS Computational Biology, 2017, 13(4): e1005474. [25] 张兵, 严睿, 何寒青, 等. 浙江省2013年麻疹疫情时空分布特征[J]. 中华流行病学杂志, 2016, 37(4): 548552. Zhang Bing, Yan Rui, He Hanqing, et al. Spatial-temporal distribution feature of measles in Zhejiang province, 2013[J]. Chinese Journal of Epidemiology, 2016, 37(4): 548552. [26] 中华人民共和国卫生部. 2006—2012年全国消除麻疹行动计划[R]. 2006. Ministry of Health, P. R. China. National Measles Eradication Action Plan 20062012[R].2006. [27] Dai B, Chen Z H, Liu Q C, et al. Duration of immunity following immunization with live measles vaccine: 15 years of observation in Zhejiang Province, China [J]. Bulletin of the World Health Organization, 1991, 69(4): 415. [28] 张延炀, 马雅婷, 王燕, 等. 2013年河南省麻疹流行病学特征及消除麻疹措施的分析[J]. 中国生物制品学杂志, 2014, 27(8): 10571060. Zhang Yanyang, Ma Yating, Wangyan, et al. Epidemiology of measles and measure of measles elimination in Henan Province, China in 2013[J]. Chinese Journal of Biologicals, 2014, 27(8): 10571060. [29] Bai Z, Liu D. Modeling seasonal measles transmission in China [J]. Communications in Nonlinear Science and Numerical Simulation, 2015, 25(1): 1926. [30] 黄蓉娜, 蔡军, 朱航, 等. 成都市实施扩大免疫规划后麻疹流行病学特征及消除麻疹策略分析[J]. 现代预防医学, 2016, 43(6): 968971, 990. Huang Rongna, Cai Jun, Zhu Hang, et al. Analysis of the epidemiological characteristics of measles and measles elimination strategies after the implementation of expanded immunization programs in Chengdu City[J]. Modern Preventive Medicine, 2016, 43(6): 968971, 990. [31] 丁亚兴, 高志刚, 孙静, 等. 天津市消除麻疹策略的实施效果评价[J]. 浙江预防医学, 2015, (3): 266268. Ding Yaxing, Gao Zhigang, Sun Jing, et al. Evaluating the implementation effect of eliminating measles in Tianjin[J]. Zhejiang Journal of Preventive Medicine, 2015, (3): 266268. [32] 丁亚兴, 朱向军, 张颖, 等. 天津市2008年麻疹减毒活疫苗强化免疫活动效果分析[J].中华疾病控制杂志, 2012, 16(6): 547548. Ding Yaxing, Zhu Xiaojun, Zhang Ying, ea al. Effect evaluation of measles attenuated live vaccine supplementary immunization activities in Tianjin City, 2008[J]. Chinese Journal of Disease Control & Prevention, 2012, 16(6): 547548. [33] 王翠玲, 吕海英, 周海, 等. 2005—2014年中山市麻疹疫情流行病学特征及强化免疫效果评价[J]. 河南预防医学杂志, 2016, 27(7): 496499. Wang Cuiling, Lü Haiying, Zhou Hai, et al. Epidemiological characteristics of measles and effects of supplementary immunization activity of measles vaccine in 20052014 in Zhongshan[J]. Henan Journal of Preventive Medicine, 2016, 27(7): 496499. [34] Pei L, Yang Y, Zhao X, et al. Identify the susceptibility profile to measles in the general population: serological survey of measles antibodies in Shaanxi province, China, in 2016[J]. Vaccine, 2017. 35(52): 72507255. [35] Fu C, Xu J, Liu W, et al. Low measles seropositivity rate among children and young adults: a seroepidemiological study in southern China in 2008[J]. Vaccine, 2010, 28(51): 82198223. [36] Tang L, Zhou Y, Pan Y, et al. Measles epidemics and seroepidemiology of population in Wujin, Changzhou city, Jiangsu province, China 2015[J]. Vaccine, 2017, 35(22): 29252929. [37] Xiong Y, Wang D, Lin W, et al. Age-related changes in serological susceptibility patterns to measles: results from a seroepidemiological study in Dongguan, China[J]. Human vaccines & immunotherapeutics, 2014, 10(4): 10971103. [38] 陆龙, 曹毅敏, 杨琼英, 等. 小月龄婴儿母传麻疹抗体水平动态变化的纵向研究[J]. 中华流行病学杂志, 2016, 37(5): 663667. Lu Long, Cao Yimin, Yang Qiongying, et al. Dynamic maternal measles antibody level in infants: a longitudinal study[J]. Chinese Journal of Epidemiology, 2016, 37(5): 663667. [39] Zhang X, Shirayama Y, Zhang Y, et al. Duration of maternally derived antibody against measles: A seroepidemiological study of infants aged under 8 months in Qinghai, China[J]. Vaccine, 2012, 30(4): 752. [40] Ma Y, Zhou J, Yang S, et al. Assessment for the impact of dust events on measles incidence in western China [J]. Atmospheric Environment, 2017, 157: 19. [41] 屠春雨. 气象因素与麻疹发病关系的研究. 中华流行病学杂志, 2004, 25(9): 826. Tu Chunyu. Study on the relationship between meteorological factors and the incidence of measles[J]. Chinese Journal of Epidemiology, 2004, 25(9): 826. [42] 霍爱梅, 赵达生, 方立群, 等. 华北地区主要呼吸道传染病与气象条件的关系. 中国医药导报, 2011, 8(32): 153156. Huo Aimei, Zhao Dasheng, Fang Liqun, et al. Relationship between main aspiratory infectious diseases and meteorological factors in North China[J]. China Medical Herald, 2011, 8(32): 153156. [43] 张晓云, 周建峰, 解以扬, 等. 天气气候对麻疹发病的影响[C]. 第26届中国气象学会年会气候环境变化与人体健康分会场论文集, 杭州, 2009: 260263. Zhang XiaoYun, Zhou Jianfeng, Xie Yiyang, et al. The impact of weather and climate on the incidence of measles[J]. Annual Meeting of China Meteorological Society Climate Change and Human Health Sessions, Hangzhou, 2009: 260263. [44] Chen G, Zhang W, Li S, et al. Is short-term exposure to ambient fine particles associated with measles incidence in China? a multi-city study [J]. Environmental Research, 2017, 156(2017): 306. [45] 张轩, 刘忠第, 贺娟. 基于“三年化疫”理论探讨麻疹发病与前期气象因素的相关性并建立预测模型[J]. 中华中医药杂志, 2014, 29(11): 34003403. Zhang Xuan, Liu Zhongdi, He Juan. Based on the "three years of epidemic" theory to investigate the correlation between the onset of measles and the meteorological factors in the early stage and establish a prediction model[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2014, 29(11): 34003403. [46] 杜志成, 张王剑, 郝元涛. 中国主要呼吸道传染病分布模式及其社会经济影响因素[J].中华疾病控制杂志, 2016, 20(1): 58. Du Zhicheng, Zhang Wangjian, Hao Yuantao. Infectious diseases Socio-economic factors Epidemiologic methods[J]. Chinese Journal of Disease Control & Prevention, 2016, 20(1): 58. [47] Li M, Liu X, Zhang L. Measles vaccination and prevention in big cities in China [J]. Human Vaccines & Immunotherapeutics, 2015, 11(7): 17771778. [48] Schenzle D. An age-structured model of pre-and post-vaccination measles transmission [J]. Ima Journal of Mathematics Applied in Medicine & Biology, 1984, 1(2): 169. [49] Ferrari M J, Grais R F, Bharti N, et al. The dynamics of measles in sub-Saharan Africa [J]. Nature, 2008, 451(7179): 679.