[1]国家药典委员会. 中华人民共和国药典(第一部)[M]. 北京:中国医药科技出版社,2015:704705.
[2]吴梅艳,李平.六味地黄丸的药理作用及临床应用综述[J]. 世界中西医结合杂志,2015,9(9):10231025.
Wu Meiyan, Li Ping. A review of the pharmacological effects and clinicalapplication of LiuweiDihuang Pill[J].Word Journal of Integrated Traditional and Western Medicine,2015,9(9):10231025.
[3]黎鹏玲.针刺结合六味地黄丸治疗妇女更年期综合征33例临床研究[J].中国医药科学,2013,3(3):112113.
Li Pengling. Clinical effect of acupuncture combined with bolus of 6 flavourglutinous rehmannia for women’s climacteric syndrome[J].China Medicine and Pharmacy,2013,3(3):112113.
[4]李艳.硝苯地平联合六味地黄丸治疗原发性高血压临床观察[J].中医临床研究,2011,3(22):47.
Li Yan. Clinical observation of treating hypertension with nifedipine combined LiuweiDihuang Wan[J].Clinical Journal of Chinese Medicine,2011,3(22):47.
[5]李涛.六味地黄丸加味治疗肝肾阴虚证绝经后骨质疏松症临床研究[J].医药论坛杂志,2014,35(8):160162.
Li Tao.Clinical Study on treatment of postmenopausal osteoporosis with liver and kidney yin deficiency syndrome by Liuwei Dihuang Pill[J].J Med Forum,2014,35(8):160162.
[6]柴彦军.六味地黄丸联合消渴丸治疗气阴两虚2型糖尿病的临床研究[J].药物评价研究,2016,39(3):445448.
Chai Yanjun.Clinical study on Xiaoke Pill combined with LiuweiDihuang Pill in treatment of type 2 diabetes mellitus with Qi and Yin deficiency[J].Drug Evaluation Research, 2016, 39(3):445448.
[7]肖召安,李光灿.六味地黄丸治疗糖尿病及其并发症的作用机制与临床应用[J].中国药房,2012,23(20):19131915.
Xiao Zhaoan, Li Guangcan.The mechanism and clinical application of Liuwei Dihuang Pill in treating diabetes mellitus and its complications[J].China Pharmacy,2012,23(20):19131915.
[8]陆向然,卞肖玲.六味地黄丸治疗糖尿病(肾阴虚证)的临床疗效[J].中国医药指南,2013,11(19):296297.
Lu Xiangran, BianXiaoling. Clinical effect of Liuwei Dihuang Pill in treating diabetes (kidney yin deficiency syndrome) [J].Guide of China Medicine,2013,11(19):296297.
[9]Yang H J, Xu H Y. Integrative pharmacology:new paradigm of modernization of Chinese medicine[J].China J Chin Mater Med,2014(2):357362.
[10] 马艳,张迎春,陶野,等. 基于整合药理学策略的元胡止痛方研究进展[J]. 中国中药杂志, 2015, 40(6):10481054.
Ma Yan, Zhang Yingchun, Tao Ye, et al. Research of YuanhuZhitongprescription based on strategy of integrative pharmacology[J].China J Chin Mater Med, 2015, 40(6):10481054.
[11] 许海玉, 刘振明, 付岩,等. 中药整合药理学计算平台的开发与应用[J]. 中国中药杂志, 2017, 42(18):36333638.
XuHaiyu, Liu Zhenming, Fu Yan, et al. Exploiture and application of an internet-based computation platform for integrative pharmacology of traditional chinese medicine[J]. China J Chin Mater Med, 2017, 42(18):36333638.
[12] 仝国辉, 张懿, 谭壮生. 地黄寡糖对实验性高血糖小鼠糖脂代谢的影响[J]. 毒理学杂志, 2011(2):117119.
Tong Guohui, Zhang Yi, Tan Zhuangsheng. Effects of Rehmannia oligosaccharides on glucose and lipid metabolism in experimental hyperglycemic mice[J].Journal of Toxicology, 2011(2):117119.
[13] Zhang R X, Jia Z P, Mao-Xing L I, et al. Molecular mechanism of Rehmanniaglutinosa oligosaccharides on improvement of insulin resistance of HepG2 cell in vitro[J]. Chinese Traditional & Herbal Drugs, 2008, 39(8):11841187.
[14] Gao D, Li Q, Gao Z, et al. Antidiabetic effects of corni fructus extract in streptozotocin-induced diabetic rats[J]. Yonsei Medical Journal, 2012, 53(4):691700.
[15] 范思思, 朱晶晶, 徐登球,等. 山茱萸总萜的降糖作用途径研究[J]. 中国药理学通报, 2017, 33(7):10141019.
Fan Sisi, Zhu Jingjing, XuDengqiu, et al.Study on the hypoglycemic action of total hawthorn[J]. Chinese Pharmacological Bulletin, 2017, 33(7):10141019.
[16] 郭洁, 张晓双, 刘继平. 山茱萸环烯醚萜总苷对晚期糖基化终末产物诱导的肾系膜炎症反应的调节[J]. 中成药, 2013, 35(10):20672072.
GuoJie, Zhang Xiaoshuang, Liu Jiping.Effect of hawthorn iridoid glycosides on renal membrane inflammation induced by advanced glycation end products[J]. Chinese Traditional Patent Medicine, 2013, 35(10):20672072.
[17] Fan Y, He Q, Luo A, et al. Characterization and antihyperglycemic activity of a polysaccharide from dioscoreaopposita thunb roots.[J]. International Journal of Molecular Sciences, 2015, 16(3):6391401.
[18] Hong H, Wang Q M, Zhao Z P, et al. Studies on antidiabetic effects of cortex Moutan polysaccharide-2b in type 2 diabetes mellitus rats[J]. Acta Pharmaceutica Sinica, 2003, 38(4):255.
[19] 陈娟, 张明华, 章丽,等. 牡丹皮苷/酚组分对糖尿病肾病大鼠肾损伤的保护作用及其机制研究[J]. 中国中药杂志, 2016, 41(11):19901998.
Chen Juan, Zhang Minghua, Zhang Li, et al. Protective effects and mechanism of glycosides/ phenol component of Moutan Cortex on renal injury of diabetic nepgropathy rats[J].China J Chin Mater Med,2016, 41(11):19901998.
[20] 黄聪亮, 郑佳俐, 李凤林,等. 茯苓多糖对Ⅱ型糖尿病小鼠降糖作用研究[J]. 食品研究与开发, 2016, 37(4):2125.
Huang Congliang, ZhengJiali, Li Fenglin, et al.Hypoglycemic Effects of Polysaccharides from WolfiporiaCocos(Schw.)Ryv.&Cilbn in TypeⅡDiabetic Mice[J]. Food Research And Development, 2016, 37(4):2125.
[21] 操兰洁, 诸夔妞, 蒋翠花,等. 泽泻提取物对STZ糖尿病大鼠的干预作用[J]. 中国药科大学学报, 2017, 48(5):601608.
Cao Lanjie, Zhu Kuiniu, Jiang Cuihua, et al. Intervention effects of the extract of AlismatisRhizoma on streptozotocin-induced type 2 diabetic rats[J]. J China Pharm Univ, 2017, 48(5):601608.
[22] Zhang L L, Xu W, Xu Y L, et al. Therapeutic potential of RhizomaAlismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology[J]. Annals of the New York Academy of Sciences, 2017, 1401(1).
[23] 赵明明, 刘丽梅. 蛋白激酶Cβ与糖尿病肾病研究的进展[J]. 上海交通大学学报(医学版), 2014, 34(4):551555.
ZhaoMingming, Liu Limei. Advances of protein kinase C beta and diabetic nephropathy[J].J Shanghai JiaotongUniv(Med Sci), 2014, 34(4):551555.
[24] Ohshiro Y, Ma R C, Yasuda Y, et al. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cβ-null mice[J]. Diabetes, 2006, 55(11):3112.
[25] Liu Y, Lei S, Gao X, et al. PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes[J]. Clinical Science, 2012, 122(4):161.
[26] Liu Z, Ma S. Recent advances on synthetic α-glucosidase inhibitors[J]. Chemmedchem, 2017, 12(11).
[27] 武香秀, 刘志跃, 付小兵,等. 糖尿病皮肤溃疡PDGF及其受体基因表达和蛋白含量的变化[J]. 内蒙古医学杂志, 2008, 40(6):643646.
Wu Xiangxiu, Liu Zhiyue, Fu Xiaobing, et al. The expression of PDGF and changes of proteins in dermal chronic ulcers in diabetes[J]. Inner Mongolia Med J,2008, 40(6):643646.
[28] Lu M, Li C. Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes.[J]. Annals of the New York Academy of Sciences, 2017(Suppl. 3).
[29] 汪建辉, 欧瑜. 葡萄糖激酶与糖尿病[J]. 药物生物技术, 2012(6):552556.
Wang Jianhui, OuYu.Glucokinase and diabetes[J].Chin J Pharm Biotec, 2012(6):552556.
[30] 庞丽琼. 糖尿病肾病相关磷脂代谢研究[D]. 北京:清华大学, 2008.
Pang Liqiong. Phospholipid metabonomic research related with diabetes nephropathy[D].Beijing: Tsinghua University, 2008.
[31] 张海燕. 磷脂酶D与糖尿病并发症[J]. 国际内分泌代谢杂志, 2000, 20(3):117120.
Zhang Haiyan.Phospholipase D and diabetic complications[J].Int J EndocrinolMetab, 2000, 20(3):117120.
[32] 冯卫生, 袁培培, 牛艳,等. 桑白皮化学拆分组分对糖尿病小鼠模型物质代谢及能量代谢的影响[J]. 世界科学技术中医药现代化, 2015, 17(3):464470.
FengWeisheng, Yuan Peipei, Niu Yan, et al.Effect of chemically splitting components of Cortex Mori on material metabolism and energy metabolism in diabetic mouse model[J]. Modernization of Traditional Chinese Medicine and Materia Materia-World Science and Technology, 2015, 17(3):464470.
[33] 邓晓威, 谢宁. 黄连素治疗2型糖尿病研究进展[J]. 中国中药杂志, 2014, 39(8):13741378.
Deng Xiaowei, XieNing.The research progress of berberine in treating type 2 diabetes[J].China J Chin Mater Med, 2014, 39(8):13741378.
[34] 朱小花. 香蕉粉对Ⅱ型糖尿病胰岛素抵抗的改善作用及其机制研究[D]. 广州:华南农业大学,2016.
Zhu Xiaohua. Researchthe improvement and mechanism on insulin resistance of raw banana powder in typeⅡ: diabetic mellitus[D]. Guangzhou: South China Agricultural University, 2016.
[35] Cheng H, Hsu Y C, Tseng C C, et al. Simvastatin alleviates diabetes-induced VEGF-mediated nephropathy via the modulation of ras signaling pathway[J]. Renal Failure, 2008, 30(5):557.
