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| Analysisand Application of the Topological Properties of Protein Complex Hypernetworks |
| HU Feng1,2,3, LIU Meng1,2,3, ZHAO Jing4, LEI Lei1,2,3
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1.Qinghai Normal University, Qinghai Xining 810016;
2.Tibetan Information Processing and Machine Translation Key Laboratory of Qinghai Province, Qinghai Xining 810008;
3.Tibetan intelligent information processing and Machine Translation Key Laboratory, Qinghai Xining 810008;
4.Army Logistics University of PLA,Chongqing, 401331 |
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Abstract This paper aims to study the topological properties of protein complex hypernetwork and to solve some practical problems based on topology characteristics of the hypernetwork, including the identification of key proteins of the network. Based on the obtained data set of protein complexes, a hypernetwork model of protein association relationship is constructed, in which each protein is represented by a node and each complex by a hyperedge. We study the topological featuresof the protein complex hypernetwork such as hyperdegree distribution, degree distribution, and sub-hypergraph centrality to identifying the key proteins. Furthermore, the results are verified by Online GEne Essentiality (OGEE) data set.
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Published: 16 May 2019
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