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复杂系统与复杂性科学  2014, Vol. 11 Issue (4): 37-40    DOI: 10.13306/j.1672-3813.2014.04.007
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基于酵母实验数据构建其蛋白质作用网络模型
陈幼文a, 刘曾荣a,b
上海大学 a.理学院数学系; b.系统生物技术研究所,上海 200444
A Yeast Protein Interaction Network Model Based on Experimental Data
CHEN Youwena, LIU Zengronga,b
a. Department of Mathematics; b. Institute of Systems Biology, Shanghai University, Shanghai 200444, China
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摘要 为考察模型在生物上的可靠性,从真实的蛋白质相互作用研究所报道的数据出发,选取合适的复制-变异的关键参数,依据复制-变异的建模思想,构建了酵母蛋白质相互作用网络模型。实证结果与目前得到认同的酵母蛋白质网络的稀疏性、无标度性和小世界性吻合。由此可知,复制-变异模型在蛋白质相互作用网络的演化模拟中是个可靠的模型。
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陈幼文
刘曾荣
关键词 酵母复制变异蛋白质相互作用网络    
Abstract:To verify the reliability of the model in biology, we build a model of yeast protein interaction network according to the duplication-divergence model based on reported experimental data. The simulation results are greatly consistent with the real protein interaction networks especially on the acknowledged characteristic of sparsity, scale-free and small world. The duplication-divergence model shows its reliability to reproduce the evolution of protein interaction networks.
Key wordsyeast    duplication    divergence    protein interaction network
收稿日期: 2013-08-10      出版日期: 2026-06-22
基金资助:国家自然科学基金(11172158)
作者简介: 陈幼文(1988-),女,浙江宁波人,硕士研究生,主要研究方向为复杂系统、复杂性科学的理论及应用。
引用本文:   
陈幼文, 刘曾荣. 基于酵母实验数据构建其蛋白质作用网络模型[J]. 复杂系统与复杂性科学, 2014, 11(4): 37-40.
CHEN Youwen, LIU Zengrong. A Yeast Protein Interaction Network Model Based on Experimental Data[J]. Complex Systems and Complexity Science, 2014, 11(4): 37-40.
链接本文:  
https://fzkx.qdu.edu.cn/CN/10.13306/j.1672-3813.2014.04.007      或      https://fzkx.qdu.edu.cn/CN/Y2014/V11/I4/37
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