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| On the Network Pharmacology of Ginseng and Astragalus with Tonifying Qi to Prevent and Treatcardio-Cerebral Diseases |
| ZHOU Rongrong1,2,LI Zhiyong3,GUO Feifei1,XU Haiyu1,TANG Shihuan1
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1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700, China;
2.School of Basic Medicine, Shanxi University of Chinese Medicine,Jinzhong 030600, China;
3.Pharmacy College of Minzu University of China, Beijing 100081, China |
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Abstract To study of the main active components, targetsof Ginseng and Astragalusand theirmolecular mechanisms of cardiac or cerebral diseases by networkpharmacology.Based on the Integrative Pharmacology of Traditional Chinese Medicine(TCMIP), we have screened the components and target information of Ginseng and Astragalus, and carried out the related GO gene function and KEGG pathway enrichment analysis, andconstructed the core target network diagram and the "Traditional Chinese Medicine-ingredient-key drug target-pathway" network diagram.The 160common target of drugs,463 drug-diseasecore target informationof are screened from Ginseng and Astragalus hebral disease.Among the 463 drug-diseasecore target information, the 62 common targets, 131 potential drug targets and 25 known disease targets are mainly involved in multiple biological processes, such as mitochondrial energy production, transformation and oxidative metabolism. This study explains the similarities and differences of the effect and application onGinseng and Astragalus,which preliminarily revealthe mechanism of combinedaction that Ginseng and Astragalus in the treatment of cardio-cerebral diseases have the effect of Tonifying Qi,and it also provides a demonstration and reference for the in-depth study of the mechanism of the effect of traditional Chinese medicine.
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Received: 12 February 2018
Published: 10 January 2019
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