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| On the Molecular Mechanism of Liuweidihuang Pillsin the Treatment of Diabetes Based on Integrated Pharmacology |
| ZHANG Jiaqi1, TANG Shihuan2, LI Defeng2, ZHANG Yi2, SU Jin2, LIU Yang1, ZHANG Aijia1, WANG Ping1,2, WANG Xijun1
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1.Chinmedomics Research Center of State Administration of TCM, Heilongjiang University of Chinese Medicine, Harbin 150040, China;
2.Institute of Chinese MateriaMedica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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Abstract To Explore the potential active ingredients and mechanism of action of Liuweidihuang Pills in the treatment of diabetesmellitus, with the help of integrated pharmacology platform for the analysis of drug targets, gene function and pathway enrichment. Then, the molecular mechanism of LiuweiDihuang Pill for the treatment of diabetes mellitus was studied by using integrated pharmacology thinking. The results showed that many metabolic pathways and components of the targets such as PRKCB, GAA, GCK were associated with diabetes mellitus. It has been speculated that Liuweidihuang Pills could regulate amino acid metabolism, energy metabolism and glucose metabolism and other metabolic disorders to achieve the therapeutic effect of diabetes mellitus.
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Received: 12 February 2018
Published: 10 January 2019
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FAN Fangfang, CHEN Shuman, YANG Hongjun, ZHANG Yi, TANG Shihuan, LI Defeng, ZHANG Yi, ZHANG Jingjing, GAO Jinhuan. The Investigation of Molecular Mechanism of Guhong Injection Against Cerebral Ischemia-Reperfusion Injury in a Network Pharmacology Approach[J]. Complex Systems and Complexity Science, 2018, 15(1): 11-17. |
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