On the Molecular Mechanism of Liuweidihuang Pillsin the Treatment of Diabetes Based on Integrated Pharmacology
ZHANG Jiaqi1, TANG Shihuan2, LI Defeng2, ZHANG Yi2, SU Jin2, LIU Yang1, ZHANG Aijia1, WANG Ping1,2, WANG Xijun1
1.Chinmedomics Research Center of State Administration of TCM, Heilongjiang University of Chinese Medicine, Harbin 150040, China; 2.Institute of Chinese MateriaMedica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Abstract：To Explore the potential active ingredients and mechanism of action of Liuweidihuang Pills in the treatment of diabetesmellitus, with the help of integrated pharmacology platform for the analysis of drug targets, gene function and pathway enrichment. Then, the molecular mechanism of LiuweiDihuang Pill for the treatment of diabetes mellitus was studied by using integrated pharmacology thinking. The results showed that many metabolic pathways and components of the targets such as PRKCB, GAA, GCK were associated with diabetes mellitus. It has been speculated that Liuweidihuang Pills could regulate amino acid metabolism, energy metabolism and glucose metabolism and other metabolic disorders to achieve the therapeutic effect of diabetes mellitus.
张佳琪, 唐仕欢, 李德凤, 张毅, 苏瑾, 刘杨, 张艾嘉, 王萍, 王喜军. 基于整合药理学平台的六味地黄丸治疗糖尿病的分子机制研究[J]. 复杂系统与复杂性科学, 2018, 15(1): 24-30.
ZHANG Jiaqi, TANG Shihuan, LI Defeng, ZHANG Yi, SU Jin, LIU Yang, ZHANG Aijia, WANG Ping, WANG Xijun. On the Molecular Mechanism of Liuweidihuang Pillsin the Treatment of Diabetes Based on Integrated Pharmacology. Complex Systems and Complexity Science, 2018, 15(1): 24-30.
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